With how overplayed, spoofed, and the amount of jokes made out of these scenes you should really laugh if you ever rewatch these movies.
http://www.ranker.com/list/movie-scenes-you-should-laugh-at-that-are-serious/stokified,
Jerry Maguire
Generic Scientology Joke. If you want to screw up your reputation join scientology and everything you've ever done will be mocked.
Rambo
Rambo with a bow and arrow was even spoofed by Gremlins of all movies.
Raging Bull
I'm not sure if this started a movie trend of repeatedly punching someone while they ask for it. If this is the origins that is pretty cool and you should laugh every time you watch it.
Full Metal Jacket
If you are in the military I doubt you could go 3 months without someone quoting this.
The Matrix
I think I've just about heard as many pill jokes as I've ever cared to hear.
Willy Wonka
This GIF is sarcastic, but the entire scene was serious. If a kid wants to get shrunk then let him. I'm obligated to help, and I can do so sarcastically is Wonka's moto. Jon Stewart brought this clip back to life when states wanted to succeed from the US.
Deer Hunter
If someone ever refers to Russian Roulette they are probably referring to this scene.
The Sixth Sense
This is very popular in spoof movies. It's not even that funny being spoofed, but when you watch it again you laugh because it makes no sense why it was so popular to reference.
Titanic
We've seen this clip way too many times.
The Silence of the Lambs
This clip has been used by so many other shows it's hilarious.